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CHM 616: Spectroscopy and its Application to Organic Molecules (4)

Prerequisites: CHM 311, CHM 312

Infrared spectroscopy: Theory of IR spectroscopy, Modes of stretching and bending, Fourier Transform Spectrometers, Background spectrum, Survey of important functional groups with examples, Chemical environment and chemical shift.

Nuclear Magnetic Resonance: Physical basis of Nuclear Magnetic Resonance spectroscopy, Chemical shift and Spin-spin coupling as functions of structure, Analysis of high-resolution NMR spectra, FT and pulse-NMR, NOE, 2D NMR (COSY, INADEQUATE, HMQC, HSQC, HMBC, NOESY, HETCOR, ROESY, TOCSY).

Mass spectroscopy: Principles of Mass Spectrometry, Ion sources (EI, CI, Field Ionization, FAB, Plasma desorption, Field desorption, Laser desorption, MALDI, Thermospray, API, ESI, APCI, APPI, Atmospheric pressure secondary ion mass spectrometry, inorganic ionization techniques, formation and fragmentation of ions, fragmentation reactions, Mass analyzers (Quadrople, Ion trap, ToF, Orbitrap, magnetic and electromagnetic analyzers), Ion cyclotron resonance and FT-MS.

Application of above techniques to organic chemistry and structural elucidation with exhaustive examples from latest publications.

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