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Indian Institute of Science Education and Research Bhopal
CHM 617: Chemical Biology (4)
Prerequisites: CHM 343
Introduction: What is Chemical Biology, Basics of Biology: Lipids, DNA, Protein, Sugars - their function and importance.
Structure of peptides and proteins: Primary, secondary and tertiary structure, Non-covalent interactions, Aggregation, Folding, Misfolding.
Microscopy and Spectroscopy in Biology: AFM, SEM, TEM, DLS, CD, UV-Vis, Fluorescence and Bioluminescence, NMR, MS.
Bioorthogonal Ligation techniques: Functional group specific ligation techniques, Strategies for attachment of synthetic molecules to biomolecules, Bioorthogonal ligations, Staudinger Ligation, Native Chemical Ligation, Intein-mediated synthesis, Site selective protein modification.
Natural and Synthetic Lipids: Natural and synthetic membranes, Vesicles. Designing synthetic vectors for DNA and siRNA, Differential Scanning Calorimetry.
DNA chemistry and its uses:Molecular recognition of DNA, Recognition and modulation of DNA, RNA, and proteins with small molecules, siRNA, RNAi and its applications, DNA-based architectures and DNA Nanotechnology.
Suggested Readings :
- Herbert Waldmann, Chemical Biology: Learning Through Case Studies; Wiley-VCH, Weinheim 2009.
- Dobson, Gerrard & Pratt, Foundations of Chemical Biology; Oxford Univ. Press; 2002.
- Miller & Tanner, Essentials Of Chemical Biology: Structure and Dynamics of Biological Macromolecules; Wiley; 2002.
- Waldman & Janning, Chemical Biology: A Practical Course; Wiley-VCH; 2004.
- Greg T. Hermanson, Bioconjugate Techniques; Academic Press, 2008.
- Joseph R. Lackowicz, Principles of Fluorescence Spectroscopy; Springer; 2006.
- Journal Articles
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