Office of Academic Affairs
Indian Institute of Science Education and Research Bhopal

CHM 313: Organic Chemistry Laboratory II (3)

Prerequisites: CHM 213, CHM 311

Learning Objectives:

This is an advanced organic chemistry practical course. In this laboratory course, students would be able to use their knowledge of selectivity in synthesis (chemo-, regio- and stereoselectivity) to plan and execute the preparation of complex organic compounds using modern C-C and C-hetero bond-forming reactions. This course would involve multi-step synthesis and chromatographic analysis of complex mixtures and advanced characterization techniques. Upon completion of this laboratory course, a student would be confident on working in a synthesis laboratory and also be able to characterize simple compounds using various modern spectroscopic techniques.

Suggested Experiments:

• Preparation of Corey-Bakshi-Shibata (CBS) reagent and enantioselective reduction of a carbonyl compound.
• Preparation of pentacyclic dione via Diels-Alder and photochemical cyclizations.
• Preparation of a Wittig salt and olefination of a carbonyl compound
• Preparation of Evans chiral auxiliary and its use in asymmetric aldol reaction
• Preparation of a Grignard reagent and its addition to a carbonyl compound
• Generation and trapping of benzyne
• Generation of a carbene: The Reimer-Tiemann reaction
• The Fischer indole synthesis
• Sonogashira/Suzuki/Heck coupling reaction
• Olefin metathesis (using Grubbs 1^st generation catalyst)
• Baylis-Hillman reaction
• Synthesis of L-Prolinamide ligands
• Synthesis of BINOL
• Synthesis of β-nitro styrene (Henry reaction)
• Ugi multicomponent coupling.

Previous

Back to Course List

Next