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Indian Institute of Science Education and Research Bhopal

CHM 312: Organic Chemistry II (4)

Prerequisites: CHM 101, CHM 211, CHM 311

Carbon-Carbon Bond Forming Reactions:

• via enolate, enamine and imine chemistry
• Grignard, cuprate and other conjugate reactions
• Olefination (Wittig, HWE, Julia and Peterson) and cyclopropanation reaction
• Radical reactions
• Other classes (via organo silane, borane and tin based reagents, Baylis-Hillman reaction)
• Introduction to Pericyclic reactions

Enantioselective Reactions:                                        

• Principles of enantioselective reactions
• Enantioselective reduction of carbonyl compounds (Corey’s oxazaborolidine catalyzed reductions and Noyori’s BINAP reduction)
• Enantioselective epoxidation of olefins (Sharpless, Jacobsen, Shi, etc.)

Introduction to Retrosynthesis:

• Basic concepts of retrosynthesis
• Demonstration of its utility with few examples

Suggested Books:

• Clayden, J., Greeves, N., Warren, S., Wothers, S. Organic Chemistry, Oxford University Press, 2001.
• Carruthers, W., Coldham, I. Some Modern Methods of Organic Synthesis, Cambridge University Press, 2004.
• Smith, M. B. and March, J. Advanced Organic Chemistry, Wiley Interscience, 2007.
• Carey, F. A., Sundberg, R. J. Advanced Organic Chemistry, Part A and B, Springer, 2007.
• Smith, M. B. Organic Synthesis, McGraw-Hill, 2001.
• Warren, S. Organic Synthesis: The Disconnection Approach, Wiley, 1983.

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