Chemistry
CHM 312: Organic Chemistry II (4)
Prerequisites: CHM 101, CHM 211, CHM 311
Carbon-Carbon Bond Forming Reactions:
- via enolate, enamine and imine chemistry
- Grignard, cuprate and other conjugate reactions
- Olefination (Wittig, HWE, Julia and Peterson) and cyclopropanation reaction
- Radical reactions
- Other classes (via organo silane, borane and tin based reagents, Baylis-Hillman reaction)
- Introduction to Pericyclic reactions
Enantioselective Reactions:
- Principles of enantioselective reactions
- Enantioselective reduction of carbonyl compounds (Corey’s oxazaborolidine catalyzed reductions and Noyori’s BINAP reduction)
- Enantioselective epoxidation of olefins (Sharpless, Jacobsen, Shi, etc.)
Introduction to Retrosynthesis:
- Basic concepts of retrosynthesis
- Demonstration of its utility with few examples
Suggested Books:
- Clayden, J., Greeves, N., Warren, S., Wothers, S. Organic Chemistry, Oxford University Press, 2001.
- Carruthers, W., Coldham, I. Some Modern Methods of Organic Synthesis, Cambridge University Press, 2004.
- Smith, M. B. and March, J. Advanced Organic Chemistry, Wiley Interscience, 2007.
- Carey, F. A., Sundberg, R. J. Advanced Organic Chemistry, Part A and B, Springer, 2007.
- Smith, M. B. Organic Synthesis, McGraw-Hill, 2001.
- Warren, S. Organic Synthesis: The Disconnection Approach, Wiley, 1983.
Previous | Back to Course List | Next |