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Indian Institute of Science Education and Research Bhopal
BIO 201 : Flow of Genetic Information (3)
Learning Objectives:
This course will help students in developing an understanding about genetic material and how information in the form of genetic blue print passes from one generation to another mediated by various biological processes.
Course Contents:
Concept of central dogma of life ad variations; Macromolecules and their organizations- DNA, RNA, Protein- Structure, conformation and organization; Chromatin structure and nucleosomes; Genes and genome organization; Plasmids and extra chromosomal DNA, Transposons; Gene regulation; DNA replication in prokaryotes and eukaryotes; Mechanism of transcription in prokaryotes and eukaryotes; Translation: Genetic code, and its degeneracy, regulation of translation process; Concept of RNA world; RNA replication and processing: capping, polyadenylation; Introduction to gene silencing, epigenetics.
Suggested Books:
- Genes – Benjamin Lewin; Jones & Bartlett Learning; 10th edition; 2009.
- Molecular biology of the gene: James D. Watson, Tania A. Baker, Stephen P. Bell, Alexander Gann, Michael Levine, Richard Losick; Benjamin Cummings; 6th edition; 2007.
- Molecular Biology of the Cell: Bruce Alberts, Alexander Johnson, Julian Lewis, Martin Raff, Keith Roberts, Peter Walter; New York: Garland Science; 5th edition; 2008.
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