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Indian Institute of Science Education and Research Bhopal
CHM 605: Bioinorganic Chemistry (4)
Prerequisites: CHM 102, CHM 302
Learning Objectives:
This course highlights the significance, specific role, and working models of transition metal complexes in various important and essential biological processes.
Course Contents:
Mineral Origin of life. Archaeal, Eucarial and Bacterial domain.
Transition metal ions in biology. Metallobiomolecules. Electron carriers, oxygen carriers, enzymes. environment.
Specific examples: Hemoglobin, Myoglobin, Hemocyanin, Hemrythrin cytochromes, Fe-S proteins, Cytochrome P-450, Nitrophorin, NO-synthase, peroxidase, catalase, Ferritin, cytochrome-C oxidase, cerulplasmin, blue copper proteins, di- and tri-copper proteins. Other enzymes like, hydrogenase, methane monooxygenase, dioxygenases, dehydratase, nitrogenase, molybdenum containing oxidase and reductase class of enzymes like sulfite oxidase, xanthine oxidase, nitrate reductase, DMSO reductase, tungsten containing formate dehydrogenase and tungsten bearing hyperthermophilic and thermophilic enzymes. Zn enzymes like carbonic anhydrase, carboxypeptidase, DNA and RNA polymerases, Nickel containing F-430, role of manganese in water splitting.
Active site analogue reaction models and structural models of these enzymes.
Environmental chemistry, auto exhaust, arsenic and other heavy metal pollutions.
Forensic chemistry; inorganic chemistry in medicine, platinum complexes, Mo=S complexes as anti-cancer drugs.
Biochemistry of main group elements.
Suggested Readings :
- Principles of Bioinorganic Chemistry, S. J. Lippard, J. M. Berg, University Science Books, 1994.
- Bioinorganic Chemistry, I. Bertini, H. B. Gray, S. J. Lippard, S. J. Valentine, Viva Books, 1st Edition, 1998.
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