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Indian Institute of Science Education and Research Bhopal

Biological Sciences

BIO 617S: Membrane Biology (2)

Diversity in biological membranes; ion channels and transporters, the structure and function of ion channels including coverage of the classical work of Hodgkin and Huxley as well a description of our current understanding of the molecular structure of ion channels as deduced from sequence analysis of the channel proteins and high resolution x-ray crystallography, and current hypotheses about the structural basis of channel selectivity and gating; freeze fracture and negative stain analysis of membrane structure, localization of antibodies and other probes by fluorescence and electron microscopy, quantitative stereology of membranes, autoradiography, and electron probe analysis. Role of membrane lipids and proteins in signaling and human diseases.

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