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Indian Institute of Science Education and Research Bhopal

BIO 609: Biophysics (4)

Basic principle of modern biophysical methods to study macromolecules from the atomic to cellular levels; Basic introduction to molecular spectroscopy: CD, fluorescence, Mass spectrometric technique, NMR spectroscopy; Introduction to X-ray crystallography, cryo electron microscopy; High resolution light microscopy, Atomic Force Microscopy, Single molecule manipulation; Introduction to Quantum Chemistry & Molecular Spectroscopy, Introduction to Statistical Mechanics; Statistical thermodynamics, lattice statistics, molecular distribution and correlation functions, molecular dynamics simulation; The problem of protein folding. Theoretical and experimental approaches to study protein folding; Introduction to Membrane Biophysics. Structure and function of membranes, experimental and theoretical tools for studying biological membrane.

Suggested Books:

• Spectroscopy for the Biological Sciences: Gordon G; Wiley-Interscience; 1st edition; 2005.
• Biophysical Chemistry: Part II: Techniques For The Study Of Biological Structure And Function by Charles R. Cantor and Paul Reinhart Schimmel; pp 503. W H Freeman and Co, Oxford. 1980.

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