Office of Academic Affairs
Indian Institute of Science Education and Research Bhopal
BIO 415: Epigenetics and Gene Regulation (4)
Prerequisites: BIO 202: Basic Genetics; BIO 301: Cell Biology; BIO 304: Molecular Biology
Learning Objectives:
This course will enable students to understand how epigenetic modifications influence gene regulation without any alteration in nucleotide composition (mutations). Beginning with the basis chromatin structure, this course will expose students to the myriad roles of epigenetics in normal development to various diseases.
Course Contents:
Introduction to theme; Chromatin, Epigenetics and Transcription, DNA methylation and demethylation, Histone modifications; Acetylation, Methylation, Phosphorylation, Ubiquitinylation, Sumoylation, Poly-ADP Ribosylation:, Heterochromatin; Histone variants; Nucleosome; Long non-coding RNA and chromatin; Epigenetics and alternative splicing; Epigenetics and mammalian development; Polycomb and Trithorax group proteins; Dosage compensation and Genomic imprinting; Epigenetics and Human Diseases, Cancer
Suggested Books:
- Thomas Jenuwein, Danny Reinberg, Marie-laure Caparros, C. David Allis, Epigenetics 1st Edition Cold Spring Harbor Laboratory Press, Usa 2008, ISBN-13 9780879698751
- Bryan M Turner, Chromatin and gene regulation, Jhon Wiley & Sons (asia) Pte Ltd 2001, ISBN-13 9780865427433
- Krishnarao Appasani, Epigenomics From Chromatin Biology to Therapeutics, Cambridge University Press 2012, ISBN-13: 978-1107003828
- Robert A. Meyers, Epigenetic Regulation and Epigenomics, John Wiley & Sons 2012, ISBN-13:978-3527326822
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